TLE4 and periodontitis: In an independent cohort GSE10334, we found that 6 candidate genes among the above 40 overlapped genes showed both significant expression differences and the same expression tendency in periodontitis samples, consistent with the result in GSE43525 (Fig 1F), including GRASP, HLA-DMB, HLA-DMA, CAB39, NCOA2 and TLE4 (Fig 1G).