Although there is no direct evidence to show that NEDD9 has a direct interaction with HBV, in the process of liver cell lesion formation and tumorigenesis caused by HBV infection, NEDD9 may promote the transformation of liver cells infected by HBV into tumor cells and the development process of tumors by participating in cell signaling pathways [18,19]. The gene discussed is NEDD9; the disease is neoplasm.