EPAS1 and pulmonary hypertension: Angus cattle with pulmonary hypertension have higher levels of the endothelial PAS domain-containing protein 1 gene (EPAS1), which codes for a hypoxia-inducible factor 2 alpha (HIF2α) twofold variant with serine (S) at position 610 and threonine (T) at position 606 [36].