Of these, phospholipase C epsilon 1 (PLCE1) has attracted our attention because of its essential role in cell growth, migration, and metastasis in various human cancers (Abnet et al., 2010; Chen et al., 2019; Chen et al., 2020; Gu et al., 2018; Kadamur and Ross, 2013; Wang et al., 2010). The gene discussed is PLCE1; the disease is cancer.