PTGS2 and early-onset autosomal dominant Alzheimer disease: Similar transcriptional upregulations have also been reported in Alzheimer’s disease (Bezzina et al., 2015; Chaudhry et al., 2008; Palop et al., 2007; Pasinetti and Aisen, 1998) Additionally, PGF2α synthesis by COX-2 pyramidal cells is also observed during seizures (Takei et al., 2012).