CD8A and neoplasm: To better understand whether naïve CD8+ T cells with high Ly6C expression have improved effector function and tumor control capability, we used cell sorting to isolate Ly6Chi and Ly6Clo naïve CD8+ T cells from OT1 mice and used adoptive cell transfer to administer these cells in a B16ova tumor-bearing mouse model (Figure 1A,B).