Another recombinant antigen epitope vaccine (RAE) composed of three epitopes (B-cell epitope 2, CD8+ T-cell epitope 7, and CD4+ T-cell epitope 11) based on the efflux pump MacB protein stimulated a Th1 immune response, with high IgG antibody titers and significant IFN-γ and IL-2 levels, and provided partial immune protection in a mouse sepsis model [89]. The gene discussed is IFNG; the disease is Sepsis.