Many studies have found an association between helminth infection and decreased prevalence of autoimmune or inflammatory diseases, linked to remodeling of the host microbiota.5,6,56 Our findings complement and extend these studies by demonstrating that CRAMP signaling bolsters immunoregulation and drives the induction of Treg cells by shifting the gut microbiota toward an immunosuppressive microenvironment. Here, CAMP is linked to helminthiasis.