In particular, blocking of V2 broadly neutralizing antibodies that recognize conformational epitopes binding to gp120s was associated with both increased susceptibility and resistance to infection; blocking of PG9 binding to A244D11gp120 was associated with susceptibility to infection while blocking of CH01 to 902114B2gp140 was associated with resistance to infection and blocking of CH01 to A244D11gp120 was highest in the Pentavalent and Trivalent groups, suggesting subtle differences in the epitopes of monoclonal antibodies elicited by the different vaccine arms. Here, TRGV9 is linked to infection.