Notably, integrin subunit alpha 3 (ITGA3) and ITGA6 showed significantly increased expression in patients with HNSCC, with higher levels of ITGA3 linked to poorer overall and relapse-free survival rates.(38) We observed the downregulation of miR-150-5p and upregulation of ITGA6 in tumor tissues, consistent with the findings of Koshizuka et al.(38) This interaction was predicted only by miRWalk. This evidence concerns the gene ITGA3 and head and neck squamous cell carcinoma.