Previous studies have shown thrombocytosis to be associated with poor prognosis, suggesting a direct role of platelets in the disease pathogenesis.(12) A study conducted by Dirix et al. measured PT and platelet counts in patients with metastatic breast cancer (n=84) and newly diagnosed women (n=23) and did not find significant differences between the groups. The gene discussed is F2; the disease is thrombocytosis disease.