SERPINE1 and endothelial dysfunction: Therefore, researchers have suggested that endothelial dysfunction and consequent alteration of the fibrinolytic system are responsible for the migration of metastatic cells.(11) This cross-sectional study aimed to explore standard coagulation tests, t-PA, PAI-1, DD, and MMP-9, in a population of Latin Americans with early breast cancer, metastatic breast cancer, and benign breast pathologies.