The intensity of NAV1 staining in the epidermis was significantly stronger in the AD skin compared to its healthy counterpart (Figure 6E, Epidermis: HC 16 ± 6.1 vs. ad 60 ± 3.2 vs. Control IgG 16 ± 6.1, p < 0.0001 in HC vs. AD, p = 0.50 in HC vs. Control IgG). Here, NAV1 is linked to Alzheimer disease.