HMGA2 and neoplasm: IVIS imaging showed that EVs with INAVA knockdown significantly inhibited tumor growth (Figure 3F) and metastases (Figure 3G) induced by HMGA2 overexpression, along with mice survival (Figure 3H) and expression levels of fibroblast activation‐related markers (Figure S3D, Supporting Information), further validating the pivotal role of HMGA2 in mediating INAVA‐induced NOF activation.