Our previous studies revealed that genotoxicity‐damaged stromal cells in TME hold remarkable potential to confer resistance on remnant cancer cells, as evidenced by the SASP factors WNT16B, AREG, and EREG.[26, 45, 47] Whether or not the ability of the SASP factors to enhance cancer chemoresistance can be reduced by apigenin remains unknown. Here, AREG is linked to cancer.