PABPN1 and oculopharyngeal muscular dystrophy: By binding to the poly(A) tail, it protects transcripts from degradation and influences their translation efficiency.[8, 9] Mutations in PABPN1 are associated with neurodegenerative diseases and oculopharyngeal muscular dystrophy, as PABPN1 mutations may lead to abnormal poly(A) tails that affect transcript stability and translation.[10, 11] PABPN1 is a crucial regulatory factor for the clearance of maternal mRNA.