It depends on zygotic genome activation during early embryonic development in mice and plays an essential role in embryogenesis.[12] In growing mouse oocytes, PABPN1 promotes the formation of nuclear polyadenylation domains (NPAD) through liquid–liquid phase separation, where it interacts with the splicing factors serine/arginine‐rich splicing factor 2 (SRSF2) and CPSF4 to regulate mRNA processing and stability.[13] This process is crucial for the development of mouse oocytes, and the loss of PABPN1 results in female infertility. This evidence concerns the gene PABPN1 and female infertility.