CD4 and AIDS: Having previously documented the traditional use of “Mukungulu,” a bark extract of Croton megalobotrys, to manage HIV/AIDS to supplement ART in northern Botswana (16, 17), here, we show that Mukungulu can act as a robust LRA ex vivo in both PBMC and isolated CD4+ T-cells from PLWH as well as in vivo using a humanized mouse model.