In particular, in some studies, Cinnamomum loureirii Nees, which down-regulates ROS, acetoside, which up-regulates Akt, CREB1, MEK1, and WNK1 and downer-gulates STAT1 and STAT3, and pectin, which down-regulates ROS, were administrated at a low concentration of 1 mg/mL or less, illustrating their potential to be utilized as main compounds for treating melanoma. This evidence concerns the gene STAT3 and melanoma.