NFKB1 and acute respiratory distress syndrome: Additionally, LPS enhances NF‐κB binding to the NLRP3 promoter, leading to the activation of the NF‐κB‐dependent NLRP3 inflammasome and facilitating the conversion of pro‐IL‐1β into its active form in an LPS‐induced ALI mouse model [7, 8, 9, 10].