NOTCH3 and Stroke: The variant‐specific NOTCH3 scores of these 6 variants (Fig 3C, D) were significantly associated with PSMD (β = 0.50, 95% CI = 0.38 to 0.62, p = 6.3 × 10−13), nWMHv (β = 0.56, 95% CI = 0.45 to 0.67, p = 1.4 × 10−17), nLV (β = 0.59, 95% CI = 0.46 to 0.72, p = 4.2 × 10−14) (Fig 4A–C), CMB count (β = 0.30, 95% CI = 0.16 to 0.45, p = 6.7 × 10−5), PVS score (β = 0.30, 95% CI = 0.13 to 0.47, p = 5.6 × 10−4) and lifetime stroke probability (hazard ratio = 2.3, 95% CI = 1.6 to 3.2, p = 1.6 × 10−6).