This was a concern raised as CF NBS was being implemented [17], as it was recognized early that the routine CFTR panels used in CF NBS, frequently including the 23 variants recommended for use in CF carrier screening by the American College of Medical Genetics and Genomics (termed the ACMG-23) [18,19], favored the identification of non-Hispanic white infants with CF. The gene discussed is CFTR; the disease is cystic fibrosis.