Various immunodiagnostic methods made it possible to find specific autoantibodies to antigens of the heart, lung, kidney, liver, large and small intestine, and endocrine glands, as well as to non-organ-specific antigens, such as elastin and collagen, chromatin proteins, cytoskeleton elements, mitochondrial proteins and lipids, etc. With more than 90 autoimmune diseases of all organs and tissues having been described, the need for such diagnostic tools is growing. The gene discussed is ELN; the disease is autoimmune disease.