For CD68, two-way ANOVA revealed significant effects of obesity (F (1, 76) = 108.4; p < 0.0001), OEA-DS application (F (1, 76) = 21.68; p < 0.0001), and a significant interaction effect of these factors (F (1, 76) = 26.07; p < 0.0001) (Figure 3C). This evidence concerns the gene CD68 and obesity due to melanocortin 4 receptor deficiency.