Application of OEA-DS was accompanied by inhibition of liver cell apoptosis in obesity, which is confirmed by both morphological examination—reduction of apoptotic foci in the “DIO+OEA-DS” group compared to the “DIO” group, and immunohistochemical methods—a decrease in the level of pro-apoptotic factors Bad and Bax in the liver is noted against the background of an increase in the level of the anti-apoptotic factor Bcl-2. This evidence concerns the gene BCL2 and obesity due to melanocortin 4 receptor deficiency.