Two-way ANOVA revealed, in the case of the ldlr gene, the significance of obesity (F (1, 20) = 29.86; p < 0.0001), OEA-DS administration (F (1, 20) = 19.60; p = 0.0003), and factorial interaction (F (1, 20) = 19.48; p = 0.0003)) for the ldlr gene. This evidence concerns the gene LDLR and obesity due to melanocortin 4 receptor deficiency.