BAX and obesity due to melanocortin 4 receptor deficiency: Two-way ANOVA, when analyzing the distribution of Bax-positive cells in the liver, revealed significant effects of obesity (F (1, 74) = 93.23; p < 0.0001), OEA-DS administration (F (1, 74) = 9.901; p = 0.0024), and the interaction of these factors (F (1, 74) = 11.80; p = 0.0010) (Figure 4B).