CD163 and obesity due to melanocortin 4 receptor deficiency: In the case of CD163, two-way ANOVA revealed a significant effect of OEA-DS administration (F (1, 56) = 21.40; p < 0.0001) and interaction of factors (F (1, 56) = 9.009; p = 0.0040), with no significant effect of obesity (Figure 3D).