CE species produced by both LCAT (e.g., CE 20:4, 22:5, 22:6) and ACAT (e.g., CE 14:0, 16:0, 18:1, 18:3) were reduced in severe IBD in male patients [10,11,63], and further research is needed to determine if the activities of both of these enzymes decline with disease severity in male patients with IBD. Here, LCAT is linked to inflammatory bowel disease.