SMAD4 and chronic myelogenous leukemia, BCR-ABL1 positive: A humanized IgG4 antibody, h4#147D, demonstrated antitumor efficacy by inducing stress response signals (e.g., JNK, p38MAPK), SMAD4 expression, and caspase-3 activation in cancer models such as pancreatic ductal adenocarcinoma (PDAC), HCC, and chronic myeloid leukemia (CML) [28].