Disruption of the functional activity of the NaPi2b transporter, caused by pathogenic variants in the SLC34A2 gene, is considered a contributing factor to a rare autosomal recessive disease known as pulmonary alveolar microlithiasis (PAM), characterized by the accumulation of concretions, primarily composed of calcium phosphates in the alveoli, leading to lung tissue damage [61]. The gene discussed is SLC34A2; the disease is pulmonary alveolar microlithiasis.