IGF1 and retinal disorder: Unfortunately, easily accessible, inducible, and cost-effective rodent DR models that generate diabetes-induced proliferative retinopathy phenotypes with a certain level of model stability do not exist, while genetically (e.g., VEGF and insulin-like growth factor 1; IGF-1) modified mice could be considered for the substitution, in that retinal neovascularization might occur [102,103].