The development of CVD, encompassing CAD, is compared with marked elevation of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukin-1 beta (IL-1β), interleukin-2 (IL-2), and interleukin-6 (IL-6). The gene discussed is TNF; the disease is coronary artery disorder.