CEBPA and leukemia: Knockdown of ecCEBPA in U937 leukemia cells resulted in increased methylation of the CEBPA gene distal promoter and decreased CEBPA mRNA levels, while ectopic expression of ecCEBPA in K562 cells led to decreased methylation of CEBPA gene distal promoter, codifying sequence, and 3′UTR as well as increased CEBPA transcript levels.