This was evident in K562, MV4-11, and Kasumi-1 AML cell lines, where pre-miR-29b transfection or viral infection reduced DNMT3A, DNMT3B, and DNMT1 mRNA and protein levels, inducing global DNA demethylation, in MV4-11 and Kasumi-1 cells, similar to the effects of DAC. Here, DNMT1 is linked to acute myeloid leukemia.