Specifically, the search string that was applied to PubMed was as follows: ((((((diabetes mellitus type-2 [Title/Abstract]) OR T2DM [Title/Abstract]) AND SGLT-2 [Title/Abstract])) OR (((SGLT-2 inhibitors [Title/Abstract]) OR SGLT2 inhibitors [Title/Abstract]) AND bone mineral density [Title/Abstract]))) OR (((BMD [Title/Abstract]) OR bone metabolism [Title/Abstract]) AND fractures [Title/Abstract]). The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.