Serum ultrafiltrates from patients with severe sepsis have demonstrated cardiotoxicity, linked to elevated levels of interleukins (IL-1, IL-8), complement component C3a, and lysozyme C. Recent findings implicate lysozyme C as a key mediator of cardiodepression in Escherichia coli sepsis models, with its inhibition showing potential to prevent myocardial depression (51, 54). This evidence concerns the gene IL1B and Sepsis.