Before transplantation, we confirmed a significant reduction of LPIN1 mRNA (Figure S2A), cell expansion, and expression of the two LSC‐markers CD34 and GPR56 in AML‐491 with two different LPIN1 shRNAs in vitro (Figures 2D,E and S2B). This evidence concerns the gene ADGRG1 and acute myeloid leukemia.