Indeed, KLF5 was noticed to co-immunoprecipitated with hypoxia-inducible factor-1α (HIF-1α) in non-small cell lung cancer cells, and KLF5 inhibition downregulated several downstream genes of HIF-1α (Li et al., 2014), while the regulation of HIF-1α on mitochondrial biogenesis varied with cell type and pathophysiological environment. Here, HIF1A is linked to non-small cell lung carcinoma.