KLF10 and obesity due to melanocortin 4 receptor deficiency: KLF10, originally named transforming growth factor inducible early gene 1 (TIEG1) has a widespread expression in mammals and participates in various cell biological processes, coordination of circadian rhythms and metabolic homeostasis, and is associated with obesity, insulin resistance, osteoporosis, cardiac hypertrophy, angiogenesis, and different types of tumors (Memon and Lee, 2018).