Biomarker studies aid in identifying sensitive patients and serve as indicators for treatment completion.15 Given the pivotal role of inflammatory cytokines in periodontal diseases and the conflicting study results on their elevation and association with clinical conditions, our study aimed to concurrently assess TNF-α and interleukin-1β levels in the saliva and GCF of patients with periodontitis, gingivitis, and healthy individuals. The gene discussed is TNF; the disease is periodontitis.