However, conflicting results from Wu et al20 and Teles et al18 showed no significant differences in salivary IL-1β levels between chronic periodontitis patients and healthy individuals, potentially influenced by saliva collection methods and exclusion criteria such as not having systemic and inflammatory diseases, etc., which may lead to the involvement of confounding factors in determining the IL-1β level and thus change in the results of the study. Here, IL1B is linked to chronic periodontitis.