Out of these 111 DMGs, we confirmed 5hmC hypomethylated genes (CCDC122, P=0.089 and NUDT15, P=0.004) and hypermethylated genes (TRMT12, P=0.003; PVT1, P=0.267, RPL30, P=0.24 and UBR5, P=0.27) with same direction GE levels in PR H/L PCa patients (n=86) (Figures 4B, C, Supplementary Tables 4A, B). This evidence concerns the gene PVT1 and posterior cortical atrophy.