Among those DMGs, the most noticeable genes included hypomethylated genes (CCDC122, NUDT15, BCCIP, and KLK10) and hypermethylated genes (PVT1, TRMT12, RPL30, UBR5, COX6C, ARMC2) in aggressive PCa patients (Supplementary Table 4A). Here, UBR5 is linked to posterior cortical atrophy.