Among those DMGs, the most noticeable genes included hypomethylated genes (CCDC122, NUDT15, BCCIP, and KLK10) and hypermethylated genes (PVT1, TRMT12, RPL30, UBR5, COX6C, ARMC2) in aggressive PCa patients (Supplementary Table 4A). The gene discussed is NUDT15; the disease is posterior cortical atrophy.