In conclusion, our study identifies important gene signatures in RP H/L men with PCa (Supplementary Table 6) and demonstrates that CCDC122, NUDT15, PVT1, TRMT12, RPL30, and UBR5 are associated with PCa aggressiveness in PR H/L men, hence, poor survival outcomes. The gene discussed is UBR5; the disease is posterior cortical atrophy.