GPT and paronychia: In terms of safety, most of the manifestations were grade 1-2 AEs, including nausea, vomiting, fatigue, rash and acnes, paronychia, elevated ALT/AST, and there were four cases (12.9%) of grade 3 AEs (including two cases of leukopenia, one case of diarrhea, and one case of interstitial pneumonitis), which were mainly related to high doses of the targeted drug.