Moreover, signaling pathways controlling growth factor receptors (such as FGFR, TGFA, EGFR, and IGFR), cytoplasmic intermediates (such as PI3K-AKT-mTOR, RAF/ERK/MAPK), and key cell differentiation pathways (such as Wnt-catenin, JAK/STAT, Hippo, Hedgehog, and Notch) all influence the progression of HCC (14). This evidence concerns the gene AKT1 and hepatocellular carcinoma.