Alcohol-induced hepatotoxic damage is associated with the upregulation of IL-8, IL-17, CXCL1, neutrophil infiltration, recruitment of bone marrow-derived or liver macrophages to the alcohol-injured liver, TGF-β secretion, and activation of myofibroblasts, which further produce excessive ECM proteins that contribute to liver fibrosis (86–88). Here, CXCL8 is linked to Hepatic fibrosis.