The FUBP protein exerts regulatory control over EMT during the metastasis of PC cells via the transforming growth factor beta (TGF-β)/Smad signaling pathway (44); additionally, it has been shown to activate the c-MYC upstream element (FUSE) to regulate c-MYC transcription in lung and breast cancers (45). Here, FUBP1 is linked to pachyonychia congenita.