reported elevated expression of 5’tiRNA-Pro-TGG in colorectal cancer (CRC) specimens, and 5’tiRNA-Pro-TGG targeted HPSE2 to regulate the proliferation and metastasis of cancer cells; metabolic analysis indicated that HPSE2 inhibits multiple metabolic pathways, including riboflavin and retinol, which can effectively reduce CRC development and metastasis (62). This evidence concerns the gene HPSE2 and cancer.