reported elevated expression of 5’tiRNA-Pro-TGG in colorectal cancer (CRC) specimens, and 5’tiRNA-Pro-TGG targeted HPSE2 to regulate the proliferation and metastasis of cancer cells; metabolic analysis indicated that HPSE2 inhibits multiple metabolic pathways, including riboflavin and retinol, which can effectively reduce CRC development and metastasis (62). This evidence concerns the gene HPSE2 and colorectal carcinoma.