tRiMetF31 is a miR-34a-guided tRNA-derived fragment, and its downstream target 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) reduces cancer cell invasion and metastasis by normalizing the tumor vasculature (Figure 4C) (68). The gene discussed is PFKFB3; the disease is neoplasm.