HIF1A and colorectal carcinoma: Similarly, in CRC, HIF-1α has been shown to accelerate ANG transcription and promote tRNA cleavage, which has been shown to increase the expression level of 5’-tiRNA-His-GTG; this, in turn, activates its downstream target, i.e., the LATS2/Hippo axis, thereby promoting the proliferation and metastasis of CRC (39).