NUP98 and hematologic disorder: The NUP98 gene, located on chromosome 11p15.5, encodes a 98 kDa nucleoporin, a nuclear pore complex component that is associated with cryptic translocations.10 The N-terminus of wild-type NUP98 is involved in the transport of RNA molecules and proteins between the cytoplasm and nucleus, as well as in the formation of biomolecular condensates, while the C-terminus plays a role in RNA binding and autoproteolytic cleavage.11,12 To date, the N-terminus of NUP98 has been fused to more than 40 partner genes in patients with hematological malignancies.