Using a db (Leptin receptor gene-deficient mouse) mouse model of diabetic cardiomyopathy, we observed that these mice exhibited a decline in the diversity of intestinal microbes, alterations in the abundance of diabetes-related microorganisms, a decrease in Firmicutes, an increase in Helicobacter, and an overall rise in intestinal microbial populations. This evidence concerns the gene LEPR and diabetic cardiomyopathy.