Haptoglobin-hemoglobin complex play a role in attenuating oxidative damage and tissue protection (di Masi et al., 2020); serum binding bead levels are elevated in populations with cardiovascular disease, malignancy, inflammation, infection, and obesity (Naryzhny and Legina, 2021). The gene discussed is HP; the disease is obesity due to melanocortin 4 receptor deficiency.