Previous studies have suggested that HIF-1α plays an important role in hypoxia-associated signaling pathways (Semenza, 2000), and HIF-1α mRNA was significantly upregulated in the plasma of patients with OSAHS and positively correlated with the severity of OSAHS (Liu et al., 2020). The gene discussed is HIF1A; the disease is obstructive sleep apnea syndrome.