Although KD, per se, is known to increase KCC2 expression in the cerebral cortex (Wang et al., 2016) and dentate gyrus (Granados-Rojas et al., 2020), little is known about regional alterations of KCC2 in the hippocampus of rats fed with KD under an epilepsy model. The gene discussed is SLC12A5; the disease is epilepsy.