SLC12A5 and epilepsy: Recent studies have reported KCC2 downregulation in multiple models of epilepsy (Chen et al., 2017; Wan et al., 2018; Wan et al., 2020; Shi et al., 2023) and humans (Aronica et al., 2007; Shimizu-Okabe et al., 2011; Gharaylou et al., 2019).