In PD, its pathogenic genes (SNCA :Synuclein Alpha, LRRK2: Leucine-Rich Repeat Kinase 2, PRKN: Parkin, and PINK1: PTEN-induced kinase 1) and risk gene (GBA1: Glucocerebrosidase 1) are closely associated with the accumulation of α-Syn (Funayama et al., 2023). The gene discussed is LRRK2; the disease is Parkinson disease.