Alterations in CD144 concentration in body fluids can serve as an early indicator of endothelial dysfunction, preceding clinical manifestations of CVD, and enabling the identification of individuals with high risk of developing CVD.10,11 Moreover, monitoring CD144 levels in patients with established cardiovascular conditions can provide insights into disease progression and therapeutic response.12,13 CD144 measurement could significantly enhance the management and outcomes of patients with CVD by providing valuable information on endothelial health and disease states. Here, CDH5 is linked to endothelial dysfunction.