ESR1 and endometrial cancer: Notably, clusters such as “Endometrial Hyperplasia” (Cluster 5), “Promising Therapeutic Target” (Cluster 6), and “Estrogen Receptor Alpha” (Cluster 7) represent earlier research topics, whereas clusters like “High-Risk Endometrial Cancer” (Cluster 1), “Recurrent Endometrial Cancer” (Cluster 2), “Tumor Mutation Burden” (Cluster 3), and “Ferroptosis-Related lncRNA” (Cluster 4) signify current research focuses.