(59) employed a therapeutic vaccine containing HPV16 E7 43-77 peptides and adjuvants to treat cervical cancer in murine models, observing a downregulation of IL-10 and TGF-β expression in M2-type macrophages and an upregulation of CXCL9 and CXCL10 chemokines in M1-type macrophages. The gene discussed is IL10; the disease is cervical cancer.