According to a recent systematic review and meta-analysis by Kang et al., various biomarkers, including HPV positivity, PD-L1 expression, body mass index, albumin, Glasgow prognostic score, lactate dehydrogenase, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio, are associated with prognostic outcomes in patients with HNSCC treated with ICIs. The gene discussed is CD274; the disease is head and neck squamous cell carcinoma.