Another group identified SPP1+ C-C motif chemokine ligand 18 (CCL18+) and SPP1+folate receptor 2 (FOLR2+) TAMs as a major platform of metastatic transcriptional programs and showed that they were correlated with poor survival outcomes of patients with HNSCC (31). The gene discussed is CCL18; the disease is head and neck squamous cell carcinoma.