Another group identified SPP1+ C-C motif chemokine ligand 18 (CCL18+) and SPP1+folate receptor 2 (FOLR2+) TAMs as a major platform of metastatic transcriptional programs and showed that they were correlated with poor survival outcomes of patients with HNSCC (31). Here, FOLR2 is linked to head and neck squamous cell carcinoma.