The results suggested that high TSHZ3 expression levels were correlated with a favorable prognosis of overall survival (OS) in lung cancer (OS: hazards ratio (HR) = 0.73, 95% confidence intervals (CI) = 0.62 to 0.86, p = 0.00023) and LUAD (HR = 0.66, 95% CI = 0.52 to 0.85, p =0.0012). This evidence concerns the gene TSHZ3 and lung cancer.