CD8A and renal cell carcinoma: In a pilot study on metastatic RCC, the immune cell infiltration of CD3+ and CD8+ T cells, CD20+ B cells, and PD-1+ immune cells were significantly increased in clear cell carcinoma patients treated with cryoablation combined with anti-CTLA-4 (tremelimumab) therapy compared to those treated with tremelimumab monotherapy (39).