GZMB and hereditary clear cell renal cell carcinoma: In another study involving a murine model of renal cell carcinoma (RCC) by Zhu et al., cryoablation combined with anti-PD-1 increased the percentage of CD8+ tumor-infiltrating T lymphocytes (TILs) and mRNA levels of interferon (IFN)-γ and granzyme B (GZMB) and inhibited distant tumor growth compared to cryoablation or anti-PD-1 alone (25).