The immune changes of RFA are generally less than that of cryoablation, for example, in colon cancer murine model, cryoablation augmented secretion of a wider array of cytokines including interleukin (IL)-1β, IL-5, IL-6, and IL-10 than RFA, with both anti-tumor and anti-inflammatory profiles (54). This evidence concerns the gene IL1B and neoplasm.