reported prolonged survival, increased levels of CD8+ IFN-γ+ T cells, higher ratios of CD8+IFNγ+ T cells/Treg cells and CD8+IFNγ+/MDSCs, and activation of DCs after treatment with HIFU plus ICI in murine pancreatic tumors compared to the control untreated tumors and those treated with either HIFU or ICI alone (110). The gene discussed is CD8A; the disease is pancreatic neoplasm.