CD4 and autoimmune polyendocrinopathy: Figures 6A–D illustrate how the activation of spleen CD3e+ T, CD4+ T, and CD8a+ T increased with the concentration of FLPs in the FLP-l, FLP-m, and FLP-h groups. Across every group tested, the FLP-h group and APS group had significantly increased CD3e+T, CD4+ T, and CD8a+ T ratios compared to the FLP-l and control groups (p < 0.05).