Transmembrane protein 147 (TMEM147) interacted with 7-dehydrocholesterol reductase (DHCR7) and enhanced its expression by promoting the STAT2 pathway, thereby conferring ferroptosis resistance and facilitating macrophage polarization into the M2-like phenotype to promote tumor growth and invasion in HCC (49) (Figure 1). The gene discussed is DHCR7; the disease is neoplasm.